Amaseli e-stem ekwelapheni isifo sikashukela sohlobo 2: sisebenza kanjani?

Isifo sikashukela sohlobo 2 yisifo esingelapheki lapho umzimba ulahlekelwa amandla awo okusebenzisa i-insulin ngempumelelo, okuholela emazingeni aphezulu kashukela egazini. Lesi simo, esaziwa ngokuthi ukumelana ne-insulin, siya ngokuya sivame kakhulu njengoba iminyaka yabantu ikhula kanye nezigameko zokukhuluphala ngokweqile. Ukwelashwa kwendabuko kufaka phakathi ukudla, ukuvivinya umzimba, ukwelapha izidakamizwa, futhi, kwezinye izimo, ukwelashwa kwe-insulin. Kodwa-ke, eminyakeni yamuva nje, ukunaka kososayensi nodokotela kuye kwaheha ukwelashwa kwesifo sikashukela sohlobo 2 ngama-stem cell. https://goodcells.com/endokrynologia/cukroviy-diabet

Ayini ama-stem cell futhi asebenza kanjani?

Ama-stem cells angamaseli omzimba ayingqayizivele anekhono lokuzivuselela futhi azihlukanise abe ezinye izinhlobo zamaseli. Angaphenduka abe amaseli ezitho nezicubu ezahlukahlukene, kufaka phakathi amaseli we-pancreas, abhekele ukukhiqizwa kwe-insulin. Ngenxa yaleli khono, ama-stem cells athathwa njengendlela ethembisayo yokubuyisela ukusebenza kwe-pancreatic ezigulini ezinesifo sikashukela sohlobo 2.

Indlela yokusebenza yama-stem cell ohlobo lwesifo sikashukela sohlobo 2

Umbono oyinhloko ngemuva kokusetshenziswa kwama-stem cell ekwelapheni uhlobo 2 sikashukela amandla awo okuvuselela amaseli e-beta awonakele noma angasebenzi. Ohlotsheni lwesifo sikashukela sohlobo 2, amanyikwe awakhiqizi i-insulin eyanele, noma umzimba awukwazi ukusebenzisa ngempumelelo i-insulin oyikhiqizayo. Amaseli e-stem angasiza ngezindlela eziningi:

1. Umehluko kumaseli e-beta. Amaseli e-stem angahlelwa kabusha elabhorethri abe amaseli e-beta, angase afakwe emzimbeni wesiguli. Lawa maseli amasha angasiza ukubuyisela amazinga e-insulin ajwayelekile futhi alawule amazinga kashukela egazini.
2. Isenzo sokulwa nokuvuvukala. Isifo sikashukela sohlobo 2 sivame ukuhambisana nokuvuvukala okungapheli, okwandisa ukumelana ne-insulin. Amaseli e-stem anezindawo zokulwa nokuvuvukala ezingasiza ukunciphisa ukuvuvukala futhi athuthukise ukuzwela kwezicubu ku-insulin.
3. Ukuvuselelwa kwezicubu. Ama-stem cells angasiza ekuvuseleleni izicubu nezitho ezilimele, okuhlanganisa imithambo yegazi namangqamuzana ezinzwa, avame ukuba nezinkinga ezihlobene nesifo sikashukela, njenge-diabetesic neuropathy kanye ne-angiopathy.

Izinzuzo zokusebenzisa ama-stem cell ekwelapheni isifo sikashukela sohlobo 2

Ukusetshenziswa kwama-stem cell ekwelapheni isifo sikashukela sohlobo 2 kunezinzuzo ezimbalwa ezingaba khona:

1. Ukuthuthukiswa komsebenzi we-pancreatic. Amaseli e-stem angasiza ukubuyisela ukusebenza kwe-gland ngokwenza ngcono ukukhiqizwa kwe-insulin nokunciphisa isidingo sokwelashwa kwe-insulin noma eminye imithi.
2. Ukunciphisa ingozi yezinkinga. Ukunciphisa ukuvuvukala nokuvuselela izicubu ezilimele kungasiza ukunciphisa ingozi yezinkinga ezifana nesifo senhliziyo nemithambo yegazi, ukwehluleka kwezinso, nokulahlekelwa ukubona.
3. Ukwelashwa komuntu siqu. Amaseli e-stem angathathwa ngokuqondile esigulini, okunciphisa ingozi yokwenqatshwa kanye nemiphumela emibi ehambisana nokufakelwa kabusha.

Ucwaningo lwamanje nezivivinyo zomtholampilo

Ucwaningo ngokusetshenziswa kwama-stem cells ekwelapheni uhlobo lwesifo sikashukela sohlobo 2 luyaqhubeka, futhi sekunemiphumela ethembisayo kakade. Ezivivinyweni eziningi zomtholampilo, kwakukhona ubufakazi bokuthuthukiswa okuphawulekayo esimweni seziguli ezithola ukwelashwa kwe-stem cell. Kodwa-ke, le ndlela yokwelapha isesigabeni sokuthuthukiswa futhi idinga izifundo ezengeziwe ukuze kuqinisekiswe ukusebenza kwayo nokuphepha esikhathini eside. Ngakho-ke, iziguli kufanele zilinganise ngokucophelela zonke izinzuzo nezingozi, zithintane nochwepheshe bezokwelapha, futhi zihlole zonke izingozi ezingaba khona ngaphambi kokuthatha isinqumo sokusebenzisa ama-stem cell ekwelapheni isifo sikashukela sohlobo 2.